Evans suffered the injury against Everton last month and Ferguson has now confirmed the 24-year-old requires surgery.
"Jonny is not available, he's getting an operation in the summer so he is out anyway," the Scot told MUTV.
Evans had been one of the players Ferguson had informed the Football Association could not be selected for Olympic duty.
Indeed, United have taken a hard-line stance on all their eligible over-age players, with the exception of Ryan Giggs, who has indicated a willingness to be involved.
"It has come out as criticism. I don't understand that," said Ferguson of his Olympic stance.
"The older players don't want to be involved.
"In the Olympics you play something a game every four days. Rio Ferdinand couldn't do that anyway.
"Ryan wants to play. I am happy with that. He is looking forward to it.
"Whether he plays three games in seven days is another matter - that is not my decision.
"But he does want to play because he has always missed out on the big tournaments with Wales."
It would not be too far of the mark to expect Ferguson has had a slightly harder task persuading Javier Hernandez not to play for Mexico.
However, after successive tournaments - World Cup and Gold Cup - during the summer, the United boss feels it is time the striker had a break.
"Mexico have five games in the summer," said Ferguson.
"After you have played a full season in England, five more games is a big task.
"We are trying to cut that down a bit.
"Mexico is a very patriotic country and all their players are patriotic. Javier wants to play.
"But we want him to get some proper rest."
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