Antonio Cassano converted from close range to put Inter in front in the 28th minute and Rodrigo Palacio made the points safe five minutes from time.
The win moved the Nerazzurri back to within four points of Juventus and just one behind second-placed Napoli.
Fiorentina were held to a 1-1 draw at struggling Chievo in an end-to-end game in which both sides wasted chances to win.
Cyril Thereau gave Chievo the lead in the 17th minute, but Gonzalo Rodriguez equalised less than a minute later.
Luca Toni hit a post for Fiorentina just before half-time, but La Viola could not find a winner.
Maicosuel scored the winner early in the second half as 10-man Udinese claimed a 1-0 win at home to Pescara.
The hosts looked to be up against it when they had Danilo sent off for a second yellow card after half an hour, but they dug in and won it when Maicosuel punished a mistake from Pescara midfielder Manuele Blasi.
Parma got a much-needed 2-1 victory over the 10 men of Sampdoria to move away from the relegation zone.
An incident late in the first half handed Parma the initiative as goalkeeper Sergio Romero was sent off for a foul on Jonathan Biabiany inside the area and Amauri dispatched the penalty.
Amauri doubled the lead early in the second half and, although Samp were handed a route back into the match with an Eder penalty nine minutes from time, Parma hung on.
Atalanta came from behind to beat fellow strugglers Siena 2-1 at the Stadio Atleti Azzurri d'Italia, leaving their opponents six points behind them at the bottom of the standings.
Giacomo Bonaventura's goal eight minutes from time settled the match after Luca Cigarini had immediately cancelled out Reginaldo's opener on the hour mark.
Siena also had Carlos Carmona sent off from the bench for complaining about a penalty which was not given.
Cagliari were 1-0 winners over Bologna thanks to Radja Nainggolan's placed finish on the hour, while Palermo and Torino drew 0-0.
The USA will wear their blue away jersey against Jamaica in their World Cup qualifier on Friday night.
Neymar's move from Santos to Barcelona is no doubt the biggest summer transfer.
Barcelona will wear this new home soccer jersey next season. They also have a new away jersey. Get them both.
The Nike Hypervenom is the latest cleat silo from Nike. It will change your game and is worn by the game's top players.
Manchester City will try and win back the Premier League title with this new soccer jersey from Nike!
Jamaica is in need of a win against the U.S. Get the jersey of the Reggae Boyz.
Germany is one of the top teams ever and they will play the US on Sunday.
The adidas Nitrocharge is the most talked about new cleat in years. It was released on May 15 and will take your pitch by storm.
The hoop soccer jersey is classic and cool. The USA hooped jersey is perfect for every fan. Get in the Gear.
England will debut their new away jersey against Brazil at the Maracana Stadium on Sunday. Get in the Gear