Max Kruse gave Freiburg a shock lead at the Waldstadion in the 50th minute after Christian Streich's side had spent much of the game defending.
Alexander Meier had a goal ruled out for offside, but there was no doubt over his third and fourth goals of the season, which earned the home side a fifth win in six games.
Karim Guede made matters worse for the visitors when he was given his marching orders in stoppage time.
Meanwhile, Wolfsburg's home misery continued as they were beaten 2-0 by Mainz at the VW-Arena, leaving them languishing in the bottom three of the table.
Junior Diaz's first goal in a Mainz shirt and an Adam Szalai effort gave the visitors a two-goal lead before the interval.
Wolfsburg were unable to recover in the second half, wasting chance after chance as their curse at home, where they have not won all season, continued.
The Liverpool 2013/14 soccer jersey is available for pre-order. The Reds are eager to compete for silver next season.
adidas has added some color to the Predator line with this new colorway. Released on May 17. Be the first to own a pair.
The adidas Nitrocharge is the most talked about new cleat in years. It was released on May 15 and will take your pitch by storm.
Borussia Dortmund hears Wembley Calling and are headed to London for the Champions League final.
Chelsea won the Europa League on Wednesday. The Blues defeated Benfica 2-1 on injury time goal from Ivanovic.
Ajax has released their away soccer jersey for the 2013/14 season. Get in the Gear.
The push for more color on their cleats, adidas has added the infrared colorway to the adiZero f50 Line.
The Juventus jersey for the 2013/14 was released earlier this week. Be the first to wear the colors of the Old Lady.
One of the top soccer cleats for control the Nike CTR360 will not let you down on the field in tight spaces.
The new PUMA evoSPEED 1.2 FG. A great new soccer cleat with classic look and first time for PUMA to be on the cleat.