Manchester United striker Javier Hernandez scored the winning goal at the Estadio Azteca as Mexico secured top spot in Group B with two rounds remaining in the Third Stage.
Mexico were the better team throughout but had to rely on Hernandez, who headed home from a Jorge Torres-Nilo cross on the hour mark.
El Salvador, meanwhile, moved up to second in in the group after defeating Guyana 3-2.
Gregory Richardson put hosts Guyana ahead in the very first minute of the match, but Osael Romero and Jaime Alas hit back for El Salvador.
Chris Nurse equalised in the 62nd minute but Rafael Burgos struck 14 minutes from time to help El Salvador climb up to five points, one above Costa Rica in both teams' fight for qualification.
The United States moved above Jamaica and into second place in Group A after a 1-0 win in Columbus.
Herculez Gomez netted the winner 10 minutes after the half-time break with a tremendous free-kick as the US avenged the 2-1 reverse in Kingston last Friday.
It was a richly deserved victory for the United States, who hit the post on three occasions during the first half.
Jurgen Klinsmann's men and Jamaica are level on seven points along with Guatemala, who edged past Antigua & Barbuda 1-0.
Forward Carlos Ruiz netted the match's only goal in the 25th minute at the Sir Vivian Richards Stadium in St John's.
Panama went top of Group C after a 2-0 win over former leaders Canada, with Rolando Blackburn and Blas Perez on-target, while Jerry Bengtson's 32nd-minute strike ensured Honduras claimed a 1-0 win over Cuba.
The new PUMA evoSPEED 1.2 FG. A great new soccer cleat with classic look and first time for PUMA to be on the cleat.
The Juventus jersey for the 2013/14 was released earlier this week. Be the first to wear the colors of the Old Lady.
One of the top soccer cleats for control the Nike CTR360 will not let you down on the field in tight spaces.
The push for more color on their cleats, adidas has added the infrared colorway to the adiZero f50 Line.
Ajax has released their away soccer jersey for the 2013/14 season. Get in the Gear.
The adidas Nitrocharge is the most talked about new cleat in years. It was released on May 15 and will take your pitch by storm.
The Liverpool 2013/14 soccer jersey is available for pre-order. The Reds are eager to compete for silver next season.
adidas has added some color to the Predator line with this new colorway. Released on May 17. Be the first to own a pair.
Borussia Dortmund hears Wembley Calling and are headed to London for the Champions League final.
Bayern Munich are kings of Germany and hope to be crowned kings of Europe at Wembley later this month!