The 30-year-old could make his debut at the weekend as Wycombe face Southend in League Two.
Manager Gary Waddock told the club's official website: "He's a good player who is experienced at this level and the one above. We've been monitoring him for a while and we're looking forward to welcoming him into the group."
Kuffour started his career on Arsenal's books, before going on to play for Swindon, Torquay, Brentford, Bournemouth, Bristol Rovers and Gillingham.
Support the USA national team with an official 2013 Centennial soccer jersey from Nike. Its Official.
The Nike Hypervenom is the latest cleat silo from Nike. It will change your game and is worn by the game's top players.
Manchester City will try and win back the Premier League title with this new soccer jersey from Nike!
Barcelona will wear this new home soccer jersey next season. They also have a new away jersey. Get them both.
The adidas Nitrocharge is the most talked about new cleat in years. It was released on May 15 and will take your pitch by storm.
England will debut their new away jersey against Brazil at the Maracana Stadium on Sunday. Get in the Gear
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Jamaica is in need of a win against the U.S. Get the jersey of the Reggae Boyz.
Neymar's move from Santos to Barcelona is no doubt the biggest summer transfer.
The USA will wear their blue away jersey against Jamaica in their World Cup qualifier on Friday night.