The Italians, who own Serie A side Udinese and Spanish outfit Granada, have been strongly linked with a move for the Hornets in recent months.
A statement on Watford's official website read: "The Board of Directors, acting on behalf of Watford Football Club, is pleased to confirm that agreement has been reached in principle for the transfer of ownership to the Pozzo family.
"Representatives from the family have been in discussions with Watford Football Club and both parties have agreed initial terms.
"Further information from Watford Football Club will be released, as appropriate, via its official website watfordfc.com."
Current owner Laurence Bassini, the frontman for the Watford FC Limited group who bought the club 15 months ago, has had a bumpy ride during his time in charge.
He had a public fallout with chairman Graham Taylor last November after the former England manager criticised him for not showing up at a fans' forum.
Taylor stepped down from his non-executive role last month.
One of the top soccer cleats for control the Nike CTR360 will not let you down on the field in tight spaces.
The new PUMA evoSPEED 1.2 FG. A great new soccer cleat with classic look and first time for PUMA to be on the cleat.
Bayern Munich are kings of Germany and hope to be crowned kings of Europe at Wembley later this month!
adidas has added some color to the Predator line with this new colorway. Released on May 17. Be the first to own a pair.
Ajax has released their away soccer jersey for the 2013/14 season. Get in the Gear.
The Juventus jersey for the 2013/14 was released earlier this week. Be the first to wear the colors of the Old Lady.
Chelsea won the Europa League on Wednesday. The Blues defeated Benfica 2-1 on injury time goal from Ivanovic.
The adidas Nitrocharge is the most talked about new cleat in years. It was released on May 15 and will take your pitch by storm.
Borussia Dortmund hears Wembley Calling and are headed to London for the Champions League final.
The Liverpool 2013/14 soccer jersey is available for pre-order. The Reds are eager to compete for silver next season.