The Black Stars began their Group D campaign by thrashing Lesotho 7-0 on June 1, but failed to make it two victories from two as Christopher Katongo's 18th-minute goal ensured Zambia ran out 1-0 winners - just as they had done when the teams met in the African Nations Cup semi-final earlier this year.
Elsewhere, South Africa failed to win for an eighth successive match. They were held to a 1-1 draw by Botswana in Gaborone.
Bafana Bafana sacked Pitso Mosimane earlier this week after managing only a 1-1 draw in their opening Group A game last weekend, with interim coach Steve Komphela expressing his optimism before kick-off on Saturday that three points would get the team back on track.
All was going well when Morgan Gould gave the visitors a 17th-minute lead, but Ofentse Nato equalised six minutes before the break to secure a point for Botswana - their first of the pool campaign after they were beaten 2-0 by Central African Republic last time out.
Newcastle striker Papiss Cisse opened the scoring for Senegal against Uganda, but Godfrey Walusimbi kept his cool to convert a penalty four minutes from time which ensured the Group J match finished 1-1.
There was late drama in Group F, with Ruben Gabriel breaking the deadlock for Nigeria in the 89th minute only for substitute John Banda to nick a 1-1 draw for Malawi two minutes into stoppage time.
The push for more color on their cleats, adidas has added the infrared colorway to the adiZero f50 Line.
The adidas Nitrocharge is the most talked about new cleat in years. It was released on May 15 and will take your pitch by storm.
The new PUMA evoSPEED 1.2 FG. A great new soccer cleat with classic look and first time for PUMA to be on the cleat.
The Liverpool 2013/14 soccer jersey is available for pre-order. The Reds are eager to compete for silver next season.
One of the top soccer cleats for control the Nike CTR360 will not let you down on the field in tight spaces.
The Juventus jersey for the 2013/14 was released earlier this week. Be the first to wear the colors of the Old Lady.
Ajax has released their away soccer jersey for the 2013/14 season. Get in the Gear.
Bayern Munich are kings of Germany and hope to be crowned kings of Europe at Wembley later this month!
Chelsea won the Europa League on Wednesday. The Blues defeated Benfica 2-1 on injury time goal from Ivanovic.
Borussia Dortmund hears Wembley Calling and are headed to London for the Champions League final.