The prolific Arsenal striker was immediately installed as the odds-on favourite for the Players' Player of the Year prize by bookmakers after being named among the nominees by the Professional Footballers' Association.
Manchester United striker Wayne Rooney, Tottenham midfielder Scott Parker and the Manchester City trio of Joe Hart, Sergio Aguero and David Silva made up a six-man shortlist, but it would be a surprise if van Persie is not named the winner on Sunday.
The 28-year-old Dutchman has struck 34 times in all competitions for the Gunners this season having shrugged off some of the injury problems that have hampered him in the past.
PFA chief executive Gordon Taylor said: "He has been amazing.
"You could pick half a dozen of his goals out for goal of the season.
"Arsenal were struggling for some time but he was a real talisman for them.
"He seems to have lifted the team and got them back believing in themselves again and looking to qualify for the Champions League, giving all the Arsenal fans some hope."
The huge impact made by Aguero since his club record £38million move to City from Atletico Madrid last summer is recognised by the fact he is also shortlisted for the Young Player of the Year prize.
The 23-year-old Argentinian has scored 28 goals for Roberto Mancini's side.
Taylor said: "We have been really fortunate to have a player like Sergio Aguero here.
"He has been a major player for Manchester City and I am not surprised there is talk of Real Madrid wanting him.
"I think Manchester City should work hard to keep him because he is a joy to watch."
Tottenham winger Gareth Bale, who won the senior award last season, is this year nominated only in the young player category.
The 22-year-old Welshman is now regarded as one of the best left-sided players in the world and Taylor would love to see him play for Great Britain at this summer's Olympics.
He said: "That would be brilliant. If he wants to play, and I hope he does, I think he should be given the opportunity.
"He fully deserves to be in a Great Britain team."
Bale's Spurs team-mate Kyle Walker, Arsenal prodigy Alex Oxlade-Chamberlain, Manchester United striker Danny Welbeck and Chelsea forward Daniel Sturridge are the other young players in contention.
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